SCOPe 2.08: Domain d2wqea_: 2wqe A:

Lineage for d2wqea_ (2wqe A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Aurora-related kinase 1 (aurora-2) [90038] (1 species)
   OPK group; AIRK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [90039] (72 PDB entries)

8. Domain d2wqea_: 2wqe A: [169565]
   automated match to d1mq4a_
   complexed with adp; mutant

Details for d2wqea_

PDB Entry: 2wqe, 2.5 Å

PDB Description: structure of s155r aurora-a somatic mutant

PDB Compounds: (A:) serine/threonine-protein kinase 6

SCOPe Domain Sequences for d2wqea_:

Sequence, based on SEQRES records:

>d2wqea_ d.144.1.7 (A:) Aurora-related kinase 1 (aurora-2) {Human (Homo sapiens) [TaxId: 9606]}
qwaledfeigrplgkgkfgnvylarekqrkfilalkvlfkaqlekagvehqlrreveiqs
hlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanalsy
chskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylppemiegrmh
dekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkh
npsqrpmlrevlehpwitanss

Sequence, based on observed residues (ATOM records):

>d2wqea_ d.144.1.7 (A:) Aurora-related kinase 1 (aurora-2) {Human (Homo sapiens) [TaxId: 9606]}
qwaledfeigrplgkgkfgnvylarekqrkfilalkvlfkaqlekagvehqlrreveiqs
hlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanalsy
chskrvihrdikpenlllgsagelkiadgtldylppemidekvdlwslgvlcyeflvgkp
pfeantyqetykrisrveftfpdfvtegardlisrllkhnpsqrpmlrevlehpwitans
s

Timeline for d2wqea_:

• d2wqea_ first appeared in SCOPe 2.01
  
• d2wqea_ appears in SCOPe 2.07