SCOPe 2.06: Domain d2wpac1: 2wpa C:1-298

Lineage for d2wpac1 (2wpa C:1-298)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (17 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (653 PDB entries)

8. Domain d2wpac1: 2wpa C:1-298 [169540]
   Other proteins in same PDB: d2wpaa2, d2wpab1, d2wpab2, d2wpac2, d2wpad1, d2wpad2
   automated match to d1vywa_
   complexed with 889, so4

Details for d2wpac1

PDB Entry: 2wpa, 2.51 Å

PDB Description: optimisation of 6,6-dimethyl pyrrolo 3,4-c pyrazoles: identification of pha-793887, a potent cdk inhibitor suitable for intravenous dosing

PDB Compounds: (C:) Cell division protein kinase 2

SCOPe Domain Sequences for d2wpac1:

Sequence; same for both SEQRES and ATOM records:

>d2wpac1 d.144.1.7 (C:1-298) automated matches {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d2wpac1:

• d2wpac1 first appeared in SCOPe 2.01, called d2wpac_
  
• d2wpac1 was called d2wpac_ in SCOPe 2.05
  
• d2wpac1 appears in SCOPe 2.07
  
• d2wpac1 appears in the current release, SCOPe 2.08