SCOPe 2.03: Domain d2wkza_: 2wkz A:

Lineage for d2wkza_ (2wkz A:)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (8 species)

7. Species Human immunodeficiency virus type 1 (isolate z2/cdc-z34 group m subtype d) [TaxId:11683] [189173] (1 PDB entry)

8. Domain d2wkza_: 2wkz A: [169425]
   automated match to d1ajva_
   complexed with 5ah

Details for d2wkza_

PDB Entry: 2wkz, 1.7 Å

PDB Description: hiv-1 protease inhibitors containing a tertiary alcohol in the transition-state mimic with improved cell-based antiviral activity

PDB Compounds: (A:) Protease

SCOPe Domain Sequences for d2wkza_:

Sequence; same for both SEQRES and ATOM records:

>d2wkza_ b.50.1.1 (A:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 (isolate z2/cdc-z34 group m subtype d) [TaxId: 11683]}
pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
qilieicghkaigtvlvgptpvniigrnlltqigctlnf

Timeline for d2wkza_:

• d2wkza_ first appeared in SCOPe 2.01
  
• d2wkza_ appears in SCOPe 2.02
  
• d2wkza_ appears in SCOPe 2.04
  
• d2wkza_ appears in the current release, SCOPe 2.08