SCOPe 2.06: Domain d2wf4a_: 2wf4 A:

Lineage for d2wf4a_ (2wf4 A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein automated matches [190156] (4 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187237] (38 PDB entries)

8. Domain d2wf4a_: 2wf4 A: [169293]
   automated match to d1w50a_
   complexed with zy4

Details for d2wf4a_

PDB Entry: 2wf4, 1.8 Å

PDB Description: human bace-1 in complex with 6-ethyl-1-methyl-n-((1s)-2-oxo-1- (phenylmethyl)-3-(tetrahydro-2h-pyran-4-ylamino)propyl)-1,3,4,6- tetrahydro(1,2)thiazepino(5,4,3-cd)indole-8-carboxamide 2,2-dioxide

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d2wf4a_:

Sequence, based on SEQRES records:

>d2wf4a_ b.50.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
emvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlssty
rdlrkgvyvpytqgkwegelgtdlvsiphgpqvtvraniaaitesdkffiqgsnwegilg
layaeiarpddslepffdslvkqthvpnlfslqlcgagfplqqsevlasvggsmiiggid
hslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkv
feaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtqqsfriti
lpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsach
vhdefrtaavegpfvtldmedcgyni

Sequence, based on observed residues (ATOM records):

>d2wf4a_ b.50.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
emvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlssty
rdlrkgvyvpytqgkwegelgtdlvsiphgpqvtvraniaaitesdkffiqgsnwegilg
layaeiarpddslepffdslvkqthvpnlfslqlcsvggsmiiggidhslytgslwytpi
rrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksikaass
tekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtqqsfritilpqqylrpvedva
tsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaavegp
fvtldmedcgyni

Timeline for d2wf4a_:

• d2wf4a_ first appeared in SCOPe 2.01
  
• d2wf4a_ appears in SCOPe 2.05
  
• d2wf4a_ appears in SCOPe 2.07
  
• d2wf4a_ appears in the current release, SCOPe 2.08