Lineage for d2wf2a_ (2wf2 A:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2058814Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2058815Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2060177Family b.50.1.2: Pepsin-like [50646] (11 protein domains)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 2060948Protein automated matches [190156] (4 species)
    not a true protein
  7. 2060973Species Human (Homo sapiens) [TaxId:9606] [187237] (38 PDB entries)
  8. 2060990Domain d2wf2a_: 2wf2 A: [169291]
    automated match to d1w50a_
    complexed with zy2

Details for d2wf2a_

PDB Entry: 2wf2 (more details), 1.8 Å

PDB Description: human bace-1 in complex with 8-ethyl-n-((1s,2r)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl) propyl)-1-methyl-3,4,7,8-tetrahydro-1h,6h-(1,2,5) thiadiazepino(5,4,3-de)quinoxaline-10-carboxamide 2,2-dioxide
PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d2wf2a_:

Sequence, based on SEQRES records: (download)

>d2wf2a_ b.50.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
emvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlssty
rdlrkgvyvpytqgkwegelgtdlvsiphgpqvtvraniaaitesdkffiqgsnwegilg
layaeiarpddslepffdslvkqthvpnlfslqlcgagfplqqsevlasvggsmiiggid
hslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkv
feaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtqqsfriti
lpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsach
vhdefrtaavegpfvtldmedcgyni

Sequence, based on observed residues (ATOM records): (download)

>d2wf2a_ b.50.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
emvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlssty
rdlrkgvyvpytqgkwegelgtdlvsiphgpqvtvraniaaitesdkffiqgsnwegilg
layaeiarpddslepffdslvkqthvpnlfslqlcgasvggsmiiggidhslytgslwyt
pirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksikaa
sstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtqqsfritilpqqylrpved
vatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaave
gpfvtldmedcgyni

SCOPe Domain Coordinates for d2wf2a_:

Click to download the PDB-style file with coordinates for d2wf2a_.
(The format of our PDB-style files is described here.)

Timeline for d2wf2a_: