SCOPe 2.07: Domain d2wd2a_: 2wd2 A:

Lineage for d2wd2a_ (2wd2 A:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.74: Carbonic anhydrase [51068] (1 superfamily)
   single sheet; 10 strands

4. Superfamily b.74.1: Carbonic anhydrase [51069] (2 families)

5. Family b.74.1.1: Carbonic anhydrase [51070] (2 proteins)
   automatically mapped to Pfam PF00194

6. Protein Carbonic anhydrase [51071] (10 species)

7. Species Human (Homo sapiens), erythrocytes, isozyme II [TaxId:9606] [51073] (971 PDB entries)
   Uniprot P00918

8. Domain d2wd2a_: 2wd2 A: [169241]
   automated match to d1cana_
   complexed with fmt, ms5, zn

Details for d2wd2a_

PDB Entry: 2wd2, 1.49 Å

PDB Description: a chimeric microtubule disruptor with efficacy on a taxane resistant cell line

PDB Compounds: (A:) Carbonic anhydrase 2

SCOPe Domain Sequences for d2wd2a_:

Sequence, based on SEQRES records:

>d2wd2a_ b.74.1.1 (A:) Carbonic anhydrase {Human (Homo sapiens), erythrocytes, isozyme II [TaxId: 9606]}
hhwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslrilnn
ghafnvefddsqdkavlkggpldgtyrliqfhfhwgsldgqgsehtvdkkkyaaelhlvh
wntkygdfgkavqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdprg
llpesldywtypgslttppllecvtwivlkepisvsseqvlkfrklnfngegepeelmvd
nwrpaqplknrqikasfk

Sequence, based on observed residues (ATOM records):

>d2wd2a_ b.74.1.1 (A:) Carbonic anhydrase {Human (Homo sapiens), erythrocytes, isozyme II [TaxId: 9606]}
hhwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslrilnn
ghafnvefddavlkggpldgtyrliqfhfhwgsldgqgsehtvdkkkyaaelhlvhwntk
ygdfgkavqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdprgllpe
sldywtypgslttppllecvtwivlkepisvsseqvlkfrklnfngegepeelmvdnwrp
aqplknrqikasfk

Timeline for d2wd2a_:

• d2wd2a_ first appeared in SCOPe 2.01
  
• d2wd2a_ appears in SCOPe 2.06
  
• d2wd2a_ appears in the current release, SCOPe 2.08