Lineage for d1ekua2 (1eku A:123-242)

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2315782Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 2315783Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 2316095Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 proteins)
    contains an additional helix in one of the crossover connections
  6. 2316133Protein Interferon-gamma [47318] (3 species)
    intertwined dimer
  7. 2316141Species Human (Homo sapiens) [TaxId:9606] [47320] (5 PDB entries)
  8. 2316154Domain d1ekua2: 1eku A:123-242 [16912]
    biologically active single chain mutant
    complexed with so4; mutant

Details for d1ekua2

PDB Entry: 1eku (more details), 2.9 Å

PDB Description: crystal structure of a biologically active single chain mutant of human ifn-gamma
PDB Compounds: (A:) interferon gamma

SCOPe Domain Sequences for d1ekua2:

Sequence; same for both SEQRES and ATOM records: (download)

>d1ekua2 a.26.1.3 (A:123-242) Interferon-gamma {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1ekua2:

Click to download the PDB-style file with coordinates for d1ekua2.
(The format of our PDB-style files is described here.)

Timeline for d1ekua2:

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