Lineage for d2w3bb_ (2w3b B:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2137011Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2137059Species Human (Homo sapiens) [TaxId:9606] [53607] (63 PDB entries)
  8. 2137064Domain d2w3bb_: 2w3b B: [169038]
    automated match to d1dlra_
    complexed with fol, k, ndp, vg9

Details for d2w3bb_

PDB Entry: 2w3b (more details), 1.27 Å

PDB Description: human dihydrofolate reductase complexed with nadph and a lipophilic antifolate selective for mycobacterium avium dhfr, 6-((2,5-diethoxyphenyl)aminomethyl)-2,4-diamino-5-methylpyrido(2,3-d)pyrimidine (sri-8686)
PDB Compounds: (B:) dihydrofolate reductase

SCOPe Domain Sequences for d2w3bb_:

Sequence; same for both SEQRES and ATOM records: (download)

>d2w3bb_ c.71.1.1 (B:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d2w3bb_:

Click to download the PDB-style file with coordinates for d2w3bb_.
(The format of our PDB-style files is described here.)

Timeline for d2w3bb_: