SCOPe 2.06: Domain d2w3ba_: 2w3b A:

Lineage for d2w3ba_ (2w3b A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (73 PDB entries)

8. Domain d2w3ba_: 2w3b A: [169037]
   automated match to d1dlra_
   complexed with fol, k, ndp, vg9

Details for d2w3ba_

PDB Entry: 2w3b, 1.27 Å

PDB Description: human dihydrofolate reductase complexed with nadph and a lipophilic antifolate selective for mycobacterium avium dhfr, 6-((2,5- diethoxyphenyl)aminomethyl)-2,4-diamino-5-methylpyrido(2,3-d) pyrimidine (sri-8686)

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d2w3ba_:

Sequence; same for both SEQRES and ATOM records:

>d2w3ba_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyekn

Timeline for d2w3ba_:

• d2w3ba_ first appeared in SCOPe 2.01
  
• d2w3ba_ appears in SCOPe 2.05
  
• d2w3ba_ appears in SCOPe 2.07
  
• d2w3ba_ appears in the current release, SCOPe 2.08