Lineage for d2w3ab_ (2w3a B:)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2477518Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2477519Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2477520Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)
  6. 2477723Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2477771Species Human (Homo sapiens) [TaxId:9606] [53607] (77 PDB entries)
  8. 2477788Domain d2w3ab_: 2w3a B: [169036]
    automated match to d1dlra_
    complexed with gol, ndp, so4, top

Details for d2w3ab_

PDB Entry: 2w3a (more details), 1.5 Å

PDB Description: human dihydrofolate reductase complexed with nadph and trimethoprim
PDB Compounds: (B:) dihydrofolate reductase

SCOPe Domain Sequences for d2w3ab_:

Sequence; same for both SEQRES and ATOM records: (download)

>d2w3ab_ c.71.1.1 (B:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d2w3ab_:

Click to download the PDB-style file with coordinates for d2w3ab_.
(The format of our PDB-style files is described here.)

Timeline for d2w3ab_: