SCOPe 2.06: Domain d1inra_: 1inr A:

Lineage for d1inra_ (1inr A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 proteins)
   contains an additional helix in one of the crossover connections

6. Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species)
   intertwined dimer, similar to interferon-gamma

7. Species Human (Homo sapiens) [TaxId:9606] [47307] (6 PDB entries)

8. Domain d1inra_: 1inr A: [16887]

Details for d1inra_

PDB Entry: 1inr, 2 Å

PDB Description: cytokine synthesis

PDB Compounds: (A:) interleukin-10

SCOPe Domain Sequences for d1inra_:

Sequence, based on SEQRES records:

>d1inra_ a.26.1.3 (A:) Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) {Human (Homo sapiens) [TaxId: 9606]}
nlpnmlrdlrdafsrvktffqmkdqldnlllkeslledfkgylgcqalsemiqfyleevm
pqaenqdpdikahvnslgenlktlrlrlrrchrflpcenkskaveqvknafnklqekgiy
kamsefdifinyieaymtmkir

Sequence, based on observed residues (ATOM records):

>d1inra_ a.26.1.3 (A:) Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) {Human (Homo sapiens) [TaxId: 9606]}
nlpnmlrdlrdafsrvktffnlllkeslledfkgylgcqalsemiqfyleevmpqaenqd
pdikahvnslgenlktlrlrlrrflpcenkskaveqvknafnklqekgiykamsefdifi
nyieaymtmkir

Timeline for d1inra_:

• d1inra_ first appeared (with stable ids) in SCOP 1.55, called d1inr__
  
• d1inra_ appears in SCOPe 2.05
  
• d1inra_ appears in SCOPe 2.07
  
• d1inra_ appears in the current release, SCOPe 2.08