SCOP 1.65: Domain d1inr__: 1inr -

Lineage for d1inr__ (1inr -)

1. Root: SCOP 1.65

2. Class a: All alpha proteins [46456] (179 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (3 families)
   there are two different topoisomers of this fold with different entanglments of the two crossover connections

5. Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (8 proteins)
   contains an additional helix in one of the crossover connections

6. Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species)
   intertwined dimer, similar to interferon-gamma

7. Species Human (Homo sapiens) [TaxId:9606] [47307] (5 PDB entries)

8. Domain d1inr__: 1inr - [16887]

Details for d1inr__

PDB Entry: 1inr, 2 Å

PDB Description: cytokine synthesis

SCOP Domain Sequences for d1inr__:

Sequence, based on SEQRES records:

>d1inr__ a.26.1.3 (-) Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) {Human (Homo sapiens)}
nlpnmlrdlrdafsrvktffqmkdqldnlllkeslledfkgylgcqalsemiqfyleevm
pqaenqdpdikahvnslgenlktlrlrlrrchrflpcenkskaveqvknafnklqekgiy
kamsefdifinyieaymtmkir

Sequence, based on observed residues (ATOM records):

>d1inr__ a.26.1.3 (-) Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) {Human (Homo sapiens)}
nlpnmlrdlrdafsrvktffnlllkeslledfkgylgcqalsemiqfyleevmpqaenqd
pdikahvnslgenlktlrlrlrrflpcenkskaveqvknafnklqekgiykamsefdifi
nyieaymtmkir

Timeline for d1inr__:

• d1inr__ first appeared (with stable ids) in SCOP 1.55
  
• d1inr__ appears in SCOP 1.63
  
• d1inr__ appears in SCOP 1.67
  
• d1inr__ appears in the current release, SCOPe 2.08, called d1inra_