Lineage for d2ilka_ (2ilk A:)

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2315782Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 2315783Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 2316095Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 proteins)
    contains an additional helix in one of the crossover connections
  6. 2316162Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species)
    intertwined dimer, similar to interferon-gamma
  7. 2316167Species Human (Homo sapiens) [TaxId:9606] [47307] (6 PDB entries)
  8. 2316168Domain d2ilka_: 2ilk A: [16885]
    complexed with so4

Details for d2ilka_

PDB Entry: 2ilk (more details), 1.6 Å

PDB Description: crystal structure of human interleukin-10 at 1.6 angstroms resolution
PDB Compounds: (A:) interleukin-10

SCOPe Domain Sequences for d2ilka_:

Sequence; same for both SEQRES and ATOM records: (download)

>d2ilka_ a.26.1.3 (A:) Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d2ilka_:

Click to download the PDB-style file with coordinates for d2ilka_.
(The format of our PDB-style files is described here.)

Timeline for d2ilka_: