SCOPe 2.05: Domain d2vomd_: 2vom D:

Lineage for d2vomd_ (2vom D:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.1: Triosephosphate isomerase (TIM) [51351] (2 families)

5. Family c.1.1.1: Triosephosphate isomerase (TIM) [51352] (2 proteins)
   automatically mapped to Pfam PF00121

6. Protein Triosephosphate isomerase [51353] (20 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51355] (5 PDB entries)

8. Domain d2vomd_: 2vom D: [168756]
   automated match to d1htia_
   mutant

Details for d2vomd_

PDB Entry: 2vom, 1.85 Å

PDB Description: structural basis of human triosephosphate isomerase deficiency. mutation e104d and correlation to solvent perturbation.

PDB Compounds: (D:) triosephosphate isomerase

SCOPe Domain Sequences for d2vomd_:

Sequence; same for both SEQRES and ATOM records:

>d2vomd_ c.1.1.1 (D:) Triosephosphate isomerase {Human (Homo sapiens) [TaxId: 9606]}
rkffvggnwkmngrkqslgeligtlnaakvpadtevvcapptayidfarqkldpkiavaa
qncykvtngaftgeispgmikdcgatwvvlghserrhvfgdsdeligqkvahalaeglgv
iacigekldereagitekvvfeqtkviadnvkdwskvvlayepvwaigtgktatpqqaqe
vheklrgwlksnvsdavaqstriiyggsvtgatckelasqpdvdgflvggaslkpefvdi
in

Timeline for d2vomd_:

• d2vomd_ first appeared in SCOPe 2.01
  
• d2vomd_ appears in SCOPe 2.04
  
• d2vomd_ appears in SCOPe 2.06
  
• d2vomd_ appears in the current release, SCOPe 2.08