SCOPe 2.08: Domain d1scfa_: 1scf A:

Lineage for d1scfa_ (1scf A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (14 proteins)

6. Protein Stem cell factor, SCF [47299] (1 species)
   forms dimer similar to the M-CSF and Flt3 ligand dimers

7. Species Human (Homo sapiens) [TaxId:9606] [47300] (3 PDB entries)

8. Domain d1scfa_: 1scf A: [16873]
   complexed with 1pe, ca

Details for d1scfa_

PDB Entry: 1scf, 2.2 Å

PDB Description: human recombinant stem cell factor

PDB Compounds: (A:) stem cell factor

SCOPe Domain Sequences for d1scfa_:

Sequence, based on SEQRES records:

>d1scfa_ a.26.1.2 (A:) Stem cell factor, SCF {Human (Homo sapiens) [TaxId: 9606]}
nvkdvtklvanlpkdymitlkyvpgmdvlpshcwisemvvqlsdsltdlldkfsnisegl
snysiidklvnivddlvecvkensskdlkksfkspeprlftpeeffrifnrsidafkdfv
vasetsdcvvs

Sequence, based on observed residues (ATOM records):

>d1scfa_ a.26.1.2 (A:) Stem cell factor, SCF {Human (Homo sapiens) [TaxId: 9606]}
nvkdvtklvanlpkdymitlkyvpgmdvlpshcwisemvvqlsdsltdlldkfsnisegl
snysiidklvnivddlvecvkspeprlftpeeffrifnrsidafkdfvvasetsdcvvs

Timeline for d1scfa_:

• d1scfa_ first appeared (with stable ids) in SCOP 1.55
  
• d1scfa_ appears in SCOPe 2.07