SCOPe 2.03: Domain d2vj9a_: 2vj9 A:

Lineage for d2vj9a_ (2vj9 A:)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein automated matches [190156] (4 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187237] (36 PDB entries)

8. Domain d2vj9a_: 2vj9 A: [168644]
   automated match to d1w50a_
   complexed with vg7

Details for d2vj9a_

PDB Entry: 2vj9, 1.6 Å

PDB Description: human bace-1 in complex with n-((1s,2r)-3-(cyclohexylamino)-2-hydroxy- 1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1-pyrrolidinyl) benzamide

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d2vj9a_:

Sequence, based on SEQRES records:

>d2vj9a_ b.50.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
emvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlssty
rdlrkgvyvpytqgkwegelgtdlvsiphgpqvtvraniaaitesdkffiqgsnwegilg
layaeiarpddslepffdslvkqthvpnlfslqlcgagfplqqsevlasvggsmiiggid
hslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkv
feaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtqqsfriti
lpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsach
vhdefrtaavegpfvtldmedcgynipqtd

Sequence, based on observed residues (ATOM records):

>d2vj9a_ b.50.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
emvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlssty
rdlrkgvyvpytqgkwegelgtdlvsiphgpqvtvraniaaitesdkffiqgsnwegilg
layaeiarpddslepffdslvkqthvpnlfslqlcggsmiiggidhslytgslwytpirr
ewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksikaasste
kfpdgfwlgeqlvcwqagttpwnifpvislylmgevtqqsfritilpqqylrpvedvats
qddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaavegpfv
tldmedcgynipqtd

Timeline for d2vj9a_:

• d2vj9a_ first appeared in SCOPe 2.01
  
• d2vj9a_ appears in SCOPe 2.02
  
• d2vj9a_ appears in SCOPe 2.04
  
• d2vj9a_ appears in the current release, SCOPe 2.08