SCOPe 2.02: Domain d2cyka_: 2cyk A:

Lineage for d2cyka_ (2cyk A:)

1. Root: SCOPe 2.02

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (14 proteins)

6. Protein Interleukin-4 (IL-4) [47291] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47292] (16 PDB entries)

8. Domain d2cyka_: 2cyk A: [16863]

Details for d2cyka_

PDB Entry: 2cyk

PDB Description: aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and nmr spectroscopy

PDB Compounds: (A:) interleukin-4

SCOPe Domain Sequences for d2cyka_:

Sequence; same for both SEQRES and ATOM records:

>d2cyka_ a.26.1.2 (A:) Interleukin-4 (IL-4) {Human (Homo sapiens) [TaxId: 9606]}
hkcditlqeiiktlnslteqktlcteltvtdifaaskntteketfcraatvlrqfyshhe
kdtrclgataqqfhrhkqlirflkrldrnlwglaglnscpvkeanqstlenflerlktim
rekyskcss

Timeline for d2cyka_:

• d2cyka_ first appeared (with stable ids) in SCOP 1.55, called d2cyk__
  
• d2cyka_ appears in SCOPe 2.01
  
• d2cyka_ appears in SCOPe 2.03
  
• d2cyka_ appears in the current release, SCOPe 2.08