SCOP 1.69: Domain d2int__: 2int -

Lineage for d2int__ (2int -)

1. Root: SCOP 1.69

2. Class a: All alpha proteins [46456] (218 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (3 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (11 proteins)

6. Protein Interleukin-4 (IL-4) [47291] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47292] (13 PDB entries)

8. Domain d2int__: 2int - [16855]

Details for d2int__

PDB Entry: 2int, 2.4 Å

PDB Description: crystal structure of recombinant human interleukin-4

SCOP Domain Sequences for d2int__:

Sequence; same for both SEQRES and ATOM records:

>d2int__ a.26.1.2 (-) Interleukin-4 (IL-4) {Human (Homo sapiens)}
hkcditlqeiiktlnslteqktlcteltvtdifaaskntteketfcraatvlrqfyshhe
kdtrclgataqqfhrhkqlirflkrldrnlwglaglnscpvkeanqstlenflerlktim
rekyskcss

Timeline for d2int__:

• d2int__ first appeared (with stable ids) in SCOP 1.55
  
• d2int__ appears in SCOP 1.67
  
• d2int__ appears in SCOP 1.71
  
• d2int__ appears in the current release, SCOPe 2.08, called d2inta_