SCOPe 2.06: Domain d2vena_: 2ven A:

Lineage for d2vena_ (2ven A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.1: Triosephosphate isomerase (TIM) [51351] (2 families)

5. Family c.1.1.1: Triosephosphate isomerase (TIM) [51352] (2 proteins)
   automatically mapped to Pfam PF00121

6. Protein Triosephosphate isomerase [51353] (20 species)

7. Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [51357] (41 PDB entries)

8. Domain d2vena_: 2ven A: [168495]
   automated match to d1dkwa_
   complexed with cit; mutant

Details for d2vena_

PDB Entry: 2ven, 2 Å

PDB Description: structure-based enzyme engineering efforts with an inactive monomeric tim variant: the importance of a single point mutation for generating an active site with suitable binding properties

PDB Compounds: (A:) glycosomal triosephosphate isomerase

SCOPe Domain Sequences for d2vena_:

Sequence, based on SEQRES records:

>d2vena_ c.1.1.1 (A:) Triosephosphate isomerase {Trypanosome (Trypanosoma brucei) [TaxId: 5691]}
skpqpiaaanwksgspdslselidlfnstsinhdvqcvvastfvhlamtkerlshpkfvi
aaqnagnadalaslkdfgvnwivlghserrwyygetneivadkvaaavasgfmviacige
tlqeresgrtavvvltqiaaiakklkkadwakvviayepvwaigtgkvatpqqaqeahal
irswvsskigadvagelrilyggsvngknartlyqqrdvngflaglkpefvdiikatq

Sequence, based on observed residues (ATOM records):

>d2vena_ c.1.1.1 (A:) Triosephosphate isomerase {Trypanosome (Trypanosoma brucei) [TaxId: 5691]}
skpqpiaaanwkslselidlfnstsinhdvqcvvastfvhlamtkerlshpkfviaaqna
gnadalaslkdfgvnwivlghserrwyygetneivadkvaaavasgfmviacigetlqer
esgrtavvvltqiaaiakklkkadwakvviayepvwkvatpqqaqeahalirswvsskig
advagelrilyggsvngknartlyqqrdvngflaglkpefvdiikatq

Timeline for d2vena_:

• d2vena_ first appeared in SCOPe 2.01
  
• d2vena_ appears in SCOPe 2.05
  
• d2vena_ appears in SCOPe 2.07
  
• d2vena_ appears in the current release, SCOPe 2.08