SCOPe 2.08: Domain d2gmfa1: 2gmf A:4-110

Lineage for d2gmfa1 (2gmf A:4-110)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (14 proteins)

6. Protein Granulocyte-macrophage colony-stimulating factor (GM-CSF) [47289] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47290] (10 PDB entries)

8. Domain d2gmfa1: 2gmf A:4-110 [16849]
   Other proteins in same PDB: d2gmfa2, d2gmfb2

Details for d2gmfa1

PDB Entry: 2gmf, 2.4 Å

PDB Description: human granulocyte macrophage colony stimulating factor

PDB Compounds: (A:) granulocyte-macrophage colony-stimulating factor

SCOPe Domain Sequences for d2gmfa1:

Sequence; same for both SEQRES and ATOM records:

>d2gmfa1 a.26.1.2 (A:4-110) Granulocyte-macrophage colony-stimulating factor (GM-CSF) {Human (Homo sapiens) [TaxId: 9606]}
rspspstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrlelyk
qglrgsltklkgpltmmashykqhcpptpetscatqiitfesfkenl

Timeline for d2gmfa1:

• d2gmfa1 first appeared (with stable ids) in SCOP 1.55, called d2gmfa_
  
• d2gmfa1 appears in SCOPe 2.07