SCOPe 2.06: Domain d1hwha_: 1hwh A:

Lineage for d1hwha_ (1hwh A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.1: Long-chain cytokines [47267] (10 proteins)

6. Protein Growth hormone, somatotropin [47276] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47277] (9 PDB entries)

8. Domain d1hwha_: 1hwh A: [16836]
   Other proteins in same PDB: d1hwhb1, d1hwhb2
   mutant

Details for d1hwha_

PDB Entry: 1hwh, 2.9 Å

PDB Description: 1:1 complex of human growth hormone mutant g120r with its soluble binding protein

PDB Compounds: (A:) growth hormone

SCOPe Domain Sequences for d1hwha_:

Sequence, based on SEQRES records:

>d1hwha_ a.26.1.1 (A:) Growth hormone, somatotropin {Human (Homo sapiens) [TaxId: 9606]}
fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleer
iqtlmgrledgsprtgqifkqtyskfdtnshnddallknygllycfrkdmdkvetflriv
qcrsvegscgf

Sequence, based on observed residues (ATOM records):

>d1hwha_ a.26.1.1 (A:) Growth hormone, somatotropin {Human (Homo sapiens) [TaxId: 9606]}
fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleer
iqtlmgrledgsprtgqifkqtyskfddallknygllycfrkdmdkvetflrivqcrsve
gscgf

Timeline for d1hwha_:

• d1hwha_ first appeared (with stable ids) in SCOP 1.55
  
• d1hwha_ appears in SCOPe 2.05
  
• d1hwha_ appears in SCOPe 2.07
  
• d1hwha_ appears in the current release, SCOPe 2.08