Lineage for d1hwha_ (1hwh A:)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1991436Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 1991437Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 1991438Family a.26.1.1: Long-chain cytokines [47267] (10 protein domains)
  6. 1991463Protein Growth hormone, somatotropin [47276] (1 species)
  7. 1991464Species Human (Homo sapiens) [TaxId:9606] [47277] (9 PDB entries)
  8. 1991472Domain d1hwha_: 1hwh A: [16836]
    Other proteins in same PDB: d1hwhb1, d1hwhb2
    mutant

Details for d1hwha_

PDB Entry: 1hwh (more details), 2.9 Å

PDB Description: 1:1 complex of human growth hormone mutant g120r with its soluble binding protein
PDB Compounds: (A:) growth hormone

SCOPe Domain Sequences for d1hwha_:

Sequence, based on SEQRES records: (download)

>d1hwha_ a.26.1.1 (A:) Growth hormone, somatotropin {Human (Homo sapiens) [TaxId: 9606]}
fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleer
iqtlmgrledgsprtgqifkqtyskfdtnshnddallknygllycfrkdmdkvetflriv
qcrsvegscgf

Sequence, based on observed residues (ATOM records): (download)

>d1hwha_ a.26.1.1 (A:) Growth hormone, somatotropin {Human (Homo sapiens) [TaxId: 9606]}
fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleer
iqtlmgrledgsprtgqifkqtyskfddallknygllycfrkdmdkvetflrivqcrsve
gscgf

SCOPe Domain Coordinates for d1hwha_:

Click to download the PDB-style file with coordinates for d1hwha_.
(The format of our PDB-style files is described here.)

Timeline for d1hwha_: