SCOPe 2.05: Domain d1a22a_: 1a22 A:

Lineage for d1a22a_ (1a22 A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.1: Long-chain cytokines [47267] (10 proteins)

6. Protein Growth hormone, somatotropin [47276] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47277] (9 PDB entries)

8. Domain d1a22a_: 1a22 A: [16833]
   Other proteins in same PDB: d1a22b1, d1a22b2

Details for d1a22a_

PDB Entry: 1a22, 2.6 Å

PDB Description: human growth hormone bound to single receptor

PDB Compounds: (A:) growth hormone

SCOPe Domain Sequences for d1a22a_:

Sequence, based on SEQRES records:

>d1a22a_ a.26.1.1 (A:) Growth hormone, somatotropin {Human (Homo sapiens) [TaxId: 9606]}
fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleer
iqtlmgrledgsprtgqifkqtyskfdtnshnddallknygllycfrkdmdkvetflriv
qcrsvegscgf

Sequence, based on observed residues (ATOM records):

>d1a22a_ a.26.1.1 (A:) Growth hormone, somatotropin {Human (Homo sapiens) [TaxId: 9606]}
fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleer
iqtlmgrlegqifkqtyskfdtdallknygllycfrkdmdkvetflrivqcrsvegscgf

Timeline for d1a22a_:

• d1a22a_ first appeared (with stable ids) in SCOP 1.55
  
• d1a22a_ appears in SCOPe 2.04
  
• d1a22a_ appears in SCOPe 2.06
  
• d1a22a_ appears in the current release, SCOPe 2.08