SCOPe 2.08: Domain d1gnca1: 1gnc A:2-175

Lineage for d1gnca1 (1gnc A:2-175)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.1: Long-chain cytokines [47267] (10 proteins)

6. Protein Granulocyte-colony stimulating factor (G-CSF) [47268] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47269] (4 PDB entries)

8. Domain d1gnca1: 1gnc A:2-175 [16821]
   Other proteins in same PDB: d1gnca2

Details for d1gnca1

PDB Entry: 1gnc

PDB Description: structure and dynamics of the human granulocyte colony-stimulating factor determined by nmr spectroscopy. loop mobility in a four-helix- bundle protein

PDB Compounds: (A:) granulocyte colony-stimulating factor

SCOPe Domain Sequences for d1gnca1:

Sequence, based on SEQRES records:

>d1gnca1 a.26.1.1 (A:2-175) Granulocyte-colony stimulating factor (G-CSF) {Human (Homo sapiens) [TaxId: 9606]}
tplgpasslpqsfllkcleqvrkiqgdgaalqeklvsecatyklchpeelvllghslgip
waplsscpsqalqlagclsqlhsglflyqgllqalegispelgptldtlqldvadfatti
wqqmeelgmapalqptqgampafasafqrraggvlvashlqsflevsyrvlrhlaqp

Sequence, based on observed residues (ATOM records):

>d1gnca1 a.26.1.1 (A:2-175) Granulocyte-colony stimulating factor (G-CSF) {Human (Homo sapiens) [TaxId: 9606]}
tplgpasslpqsfllkcleqvrkiqgdgaalqeklcatyklchpeelvllghslgipwap
lsscpsqalqlagclsqlhsglflyqgllqalegispelgptldtlqldvadfattiwqq
meelgmapalqptqgampafasafqrraggvlvashlqsflevsyrvlrhlaqp

Timeline for d1gnca1:

• d1gnca1 first appeared (with stable ids) in SCOP 1.55, called d1gnc__
  
• d1gnca1 was called d1gnca_ in SCOPe 2.07