SCOPe 2.08: Domain d2r3fa_: 2r3f A:

Lineage for d2r3fa_ (2r3f A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
   Uniprot P24941

8. Domain d2r3fa_: 2r3f A: [167949]
   automated match to d1aq1a_
   complexed with sc8

Details for d2r3fa_

PDB Entry: 2r3f, 1.5 Å

PDB Description: Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor

PDB Compounds: (A:) Cell division protein kinase 2

SCOPe Domain Sequences for d2r3fa_:

Sequence, based on SEQRES records:

>d2r3fa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Sequence, based on observed residues (ATOM records):

>d2r3fa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirvpstaireisllkelnhpnivkll
dvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrd
lkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyystavdiw
slgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqd
fskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d2r3fa_:

• d2r3fa_ first appeared in SCOPe 2.01
  
• d2r3fa_ appears in SCOPe 2.07