SCOPe 2.07: Domain d2qxsa_: 2qxs A:

Lineage for d2qxsa_ (2qxs A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (82 PDB entries)
   Uniprot P03372 307-551

8. Domain d2qxsa_: 2qxs A: [167872]
   automated match to d1qkua_
   protein/DNA complex; complexed with ral; mutant

Details for d2qxsa_

PDB Entry: 2qxs, 1.7 Å

PDB Description: crystal structure of antagonizing mutant 536s of the estrogen receptor alpha ligand binding domain complexed to raloxifene

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d2qxsa_:

Sequence, based on SEQRES records:

>d2qxsa_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemld
ah

Sequence, based on observed residues (ATOM records):

>d2qxsa_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydprpfsasmmglltnladrelvhminwakrvpgf
vdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdm
llatssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldkitdtlihlm
akagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemldah

Timeline for d2qxsa_:

• d2qxsa_ first appeared in SCOPe 2.01
  
• d2qxsa_ appears in SCOPe 2.06
  
• d2qxsa_ appears in the current release, SCOPe 2.08