SCOPe 2.08: Domain d2qe2a_: 2qe2 A:

Lineage for d2qe2a_ (2qe2 A:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus [TaxId:11103] [56697] (72 PDB entries)

8. Domain d2qe2a_: 2qe2 A: [167555]
   automated match to d1nb4a_
   complexed with 452

Details for d2qe2a_

PDB Entry: 2qe2, 2.9 Å

PDB Description: Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d2qe2a_:

Sequence, based on SEQRES records:

>d2qe2a_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
llrhhnmvyattsrsaglrqkkvtfdrlqvlddhyrdvlkemkakastvkakllsveeac
kltpphsakskfgygakdvrnlsskavnhihsvwkdlledtvtpidttimaknevfcvqp
ekggrkparlivfpdlgvrvcekmalydvvstlpqvvmgssygfqyspgqrveflvntwk
skknpmgfsydtrcfdstvtendirveesiyqccdlapearqaikslterlyiggpltns
kgqncgyrrcrasgvlttscgntltcylkasaacraaklqdctmlvngddlvvicesagt
qedaaslrvfteamtrysappgdppqpeydlelitscssnvsvahdasgkrvyyltrdpt
tplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqlekaldcqiyg
acysiepldlpqiierlhglsafslhsyspgeinrvasclrklgvpplrvwrhrarsvra
rllsqggraatcgkylfnwavktklkltpipaasqldlsgwfvagysggdiyh

Sequence, based on observed residues (ATOM records):

>d2qe2a_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
llrhhnmvyattsrsaglrqkkvtfdrlqvlddhyrdvlkemkakastvkakllsveeac
kltpphsafgygakdvrnlsskavnhihsvwkdlledpidttimaknevfcvqpeggrkp
arlivfpdlgvrvcekmalydvvstlpqvvmgssygfqyspgqrveflvntwkskknpmg
fsydtrcfdstvtendirveesiyqccdlapearqaikslterlyiggpltnskgqncgy
rrcrasgvlttscgntltcylkasaacraaklqdctmlvngddlvvicesagtqedaasl
rvfteamtryppgdppqpeydlelitscssnvsvahdasgkrvyyltrdpttplaraawe
tarhtpvnswlgniimyaptlwarmilmthffsillaqeqlekaldcqiygacysiepld
lpqiierlhglsafslhsyspgeinrvasclrklgvpplrvwrhrarsvrarllsqggra
atcgkylfnwavktklkltpipaaslsgwfvagysggdiyh

Timeline for d2qe2a_:

• d2qe2a_ first appeared in SCOPe 2.01
  
• d2qe2a_ appears in SCOPe 2.07