Lineage for d2q11c_ (2q11 C:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2058814Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2058815Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2060177Family b.50.1.2: Pepsin-like [50646] (11 protein domains)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 2060235Protein beta-secretase (memapsin) [50671] (1 species)
  7. 2060236Species Human (Homo sapiens) [TaxId:9606] [50672] (281 PDB entries)
    Uniprot P56817 58-446 ! Uniprot P56817 60-447
  8. 2060631Domain d2q11c_: 2q11 C: [167387]
    automated match to d1fkna_
    complexed with xx4

Details for d2q11c_

PDB Entry: 2q11 (more details), 2.4 Å

PDB Description: Structure of BACE complexed to compound 1
PDB Compounds: (C:) Beta-secretase 1

SCOPe Domain Sequences for d2q11c_:

Sequence; same for both SEQRES and ATOM records: (download)

>d2q11c_ b.50.1.2 (C:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
sfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqls
styrdlrkgvyvpytqgkwegelgtdlvsiphgpqvtvraniaaitesdkffiqgsnweg
ilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplqqsevlasvggsmiig
gidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlp
kkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtqqsfr
itilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavs
achvhdefrtaavegpfvtldmedcgyn

SCOPe Domain Coordinates for d2q11c_:

Click to download the PDB-style file with coordinates for d2q11c_.
(The format of our PDB-style files is described here.)

Timeline for d2q11c_: