SCOPe 2.06: Domain d2q11b_: 2q11 B:

Lineage for d2q11b_ (2q11 B:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (281 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d2q11b_: 2q11 B: [167386]
   automated match to d1fkna_
   complexed with xx4

Details for d2q11b_

PDB Entry: 2q11, 2.4 Å

PDB Description: structure of bace complexed to compound 1

PDB Compounds: (B:) Beta-secretase 1

SCOPe Domain Sequences for d2q11b_:

Sequence; same for both SEQRES and ATOM records:

>d2q11b_ b.50.1.2 (B:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
sfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqls
styrdlrkgvyvpytqgkwegelgtdlvsiphgpqvtvraniaaitesdkffiqgsnweg
ilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplqqsevlasvggsmiig
gidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlp
kkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtqqsfr
itilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavs
achvhdefrtaavegpfvtldmedcgyn

Timeline for d2q11b_:

• d2q11b_ first appeared in SCOPe 2.01
  
• d2q11b_ appears in SCOPe 2.05
  
• d2q11b_ appears in SCOPe 2.07
  
• d2q11b_ appears in the current release, SCOPe 2.08