SCOPe 2.03: Domain d2puua_: 2puu A:

Lineage for d2puua_ (2puu A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Mouse (Mus musculus) [TaxId:10090] [56131] (22 PDB entries)

8. Domain d2puua_: 2puu A: [167277]
   automated match to d1a9ua_
   complexed with g2g

Details for d2puua_

PDB Entry: 2puu, 2.5 Å

PDB Description: crystal structure of p38 complex with 1-(5-tert-butyl-2-p-tolyl-2h- pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)naphthalen-1- yl]urea

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d2puua_:

Sequence, based on SEQRES records:

>d2puua_ d.144.1.7 (A:) MAP kinase p38 {Mouse (Mus musculus) [TaxId: 10090]}
rptfyrqelaktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcakltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyva
trwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpga
ellkkissesarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaaqala
hayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Sequence, based on observed residues (ATOM records):

>d2puua_ d.144.1.7 (A:) MAP kinase p38 {Mouse (Mus musculus) [TaxId: 10090]}
rptfyrqelaktiwevperyqnlspvsvcaafdtktghrvavkklsrpfqsiihakrtyr
elrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcakltddhvqfl
iyqilrglkyihsadiihrdlkpsnlavnedcelkildfgvatrwyrapeimlnwmhynq
tvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkissesarnyiqsl
aqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdpddepvadp
ydqsfesrdllidewksltydevisfvppp

Timeline for d2puua_:

• d2puua_ first appeared in SCOPe 2.01
  
• d2puua_ appears in SCOPe 2.02
  
• d2puua_ appears in SCOPe 2.04
  
• d2puua_ appears in the current release, SCOPe 2.08