SCOPe 2.05: Domain d2pd6d_: 2pd6 D:

Lineage for d2pd6d_ (2pd6 D:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.0: automated matches [191313] (1 protein)
   not a true family

6. Protein automated matches [190069] (203 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186944] (39 PDB entries)

8. Domain d2pd6d_: 2pd6 D: [167141]
   automated match to d1q7ba_
   complexed with nad

Details for d2pd6d_

PDB Entry: 2pd6, 2 Å

PDB Description: Structure of human hydroxysteroid dehydrogenase type 8, HSD17B8

PDB Compounds: (D:) Estradiol 17-beta-dehydrogenase 8

SCOPe Domain Sequences for d2pd6d_:

Sequence, based on SEQRES records:

>d2pd6d_ c.2.1.0 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nrlrsalalvtgagsgigravsvrlagegatvaacdldraaaqetvrllggpgskegppr
gnhaafqadvsearaarclleqvqacfsrppsvvvscagitqdefllhmseddwdkviav
nlkgtflvtqaaaqalvsngcrgsiinissivgkvgnvgqtnyaaskagvigltqtaare
lgrhgircnsvlpgfiatpmtqkvpqkvvdkitemipmghlgdpedvadvvaflasedsg
yitgtsvevtgglf

Sequence, based on observed residues (ATOM records):

>d2pd6d_ c.2.1.0 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nrlrsalalvtgagsgigravsvrlagegatvaacdldraaaqetvrllnhaafqadvse
araarclleqvqacfsrppsvvvscagitqdefllhmseddwdkviavnlkgtflvtqaa
aqalvsngcrgsiinissivgkvgnvgqtnyaaskagvigltqtaarelgrhgircnsvl
pgfiatpmtqkvpqkvvdkitemipmghlgdpedvadvvaflasedsgyitgtsvevtgg
lf

Timeline for d2pd6d_:

• d2pd6d_ first appeared in SCOPe 2.01
  
• d2pd6d_ appears in SCOPe 2.04
  
• d2pd6d_ appears in SCOPe 2.06
  
• d2pd6d_ appears in the current release, SCOPe 2.08