SCOPe 2.06: Domain d2pd6b_: 2pd6 B:

Lineage for d2pd6b_ (2pd6 B:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.0: automated matches [191313] (1 protein)
   not a true family

6. Protein automated matches [190069] (239 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186944] (46 PDB entries)

8. Domain d2pd6b_: 2pd6 B: [167139]
   Other proteins in same PDB: d2pd6a2
   automated match to d1q7ba_
   complexed with nad

Details for d2pd6b_

PDB Entry: 2pd6, 2 Å

PDB Description: Structure of human hydroxysteroid dehydrogenase type 8, HSD17B8

PDB Compounds: (B:) Estradiol 17-beta-dehydrogenase 8

SCOPe Domain Sequences for d2pd6b_:

Sequence, based on SEQRES records:

>d2pd6b_ c.2.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lrsalalvtgagsgigravsvrlagegatvaacdldraaaqetvrllggpgskegpprgn
haafqadvsearaarclleqvqacfsrppsvvvscagitqdefllhmseddwdkviavnl
kgtflvtqaaaqalvsngcrgsiinissivgkvgnvgqtnyaaskagvigltqtaarelg
rhgircnsvlpgfiatpmtqkvpqkvvdkitemipmghlgdpedvadvvaflasedsgyi
tgtsvevtgglf

Sequence, based on observed residues (ATOM records):

>d2pd6b_ c.2.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lrsalalvtgagsgigravsvrlagegatvaacdldraaaqetvrllgnhaafqadvsea
raarclleqvqacfsrppsvvvscagitqdefllhmseddwdkviavnlkgtflvtqaaa
qalvsngcrgsiinissivgkvgnvgqtnyaaskagvigltqtaarelgrhgircnsvlp
gfiatpmtqkvpqkvvdkitemipmghlgdpedvadvvaflasedsgyitgtsvevtggl
f

Timeline for d2pd6b_:

• d2pd6b_ first appeared in SCOPe 2.01
  
• d2pd6b_ appears in SCOPe 2.05
  
• d2pd6b_ appears in SCOPe 2.07
  
• d2pd6b_ appears in the current release, SCOPe 2.08