Lineage for d2p2ha1 (2p2h A:815-1172)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2545083Protein Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  7. 2545084Species Human (Homo sapiens) [TaxId:9606] [56161] (25 PDB entries)
  8. 2545092Domain d2p2ha1: 2p2h A:815-1172 [166956]
    Other proteins in same PDB: d2p2ha2
    automated match to d1vr2a_
    complexed with 994

Details for d2p2ha1

PDB Entry: 2p2h (more details), 1.95 Å

PDB Description: crystal structure of the vegfr2 kinase domain in complex with a pyridinyl-triazine inhibitor
PDB Compounds: (A:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d2p2ha1:

Sequence, based on SEQRES records: (download)

>d2p2ha1 d.144.1.7 (A:815-1172) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdr

Sequence, based on observed residues (ATOM records): (download)

>d2p2ha1 d.144.1.7 (A:815-1172) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
ehaerlpydaskwefprdrlklgkplgrqvieadafgidktatcrtvavkmlkegathse
hralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpy
kvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfg
larlplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegt
rmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqdr

SCOPe Domain Coordinates for d2p2ha1:

Click to download the PDB-style file with coordinates for d2p2ha1.
(The format of our PDB-style files is described here.)

Timeline for d2p2ha1:

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Domains from same chain:
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d2p2ha2