SCOPe 2.01: Domain d2p15a_: 2p15 A:

Lineage for d2p15a_ (2p15 A:)

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (57 PDB entries)
   Uniprot P03372 307-551

8. Domain d2p15a_: 2p15 A: [166933]
   automated match to d1qkua_
   complexed with ezt

Details for d2p15a_

PDB Entry: 2p15, 1.94 Å

PDB Description: crystal structure of the er alpha ligand binding domain with the agonist ortho-trifluoromethylphenylvinyl estradiol

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d2p15a_:

Sequence, based on SEQRES records:

>d2p15a_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitd
tlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdllleml
dahrl

Sequence, based on observed residues (ATOM records):

>d2p15a_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
slalsltadqmvsalldaeppilyseyrpfseasmmglltnladrelvhminwakrvpgf
vdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdm
llatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtli
hlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldah
rl

Timeline for d2p15a_:

• d2p15a_ is new in SCOPe 2.01-stable
  
• d2p15a_ appears in SCOPe 2.02
  
• d2p15a_ appears in the current release, SCOPe 2.08