SCOPe 2.08: Domain d2onne_: 2onn E:

Lineage for d2onne_ (2onn E:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.82: ALDH-like [53719] (1 superfamily)
   consists of two similar domains with 3 layers (a/b/a) each; duplication
   core: parallel beta-sheet of 5 strands, order 32145

4. Superfamily c.82.1: ALDH-like [53720] (3 families)
   binds NAD differently from other NAD(P)-dependent oxidoreductases

5. Family c.82.1.1: ALDH-like [53721] (6 proteins)

6. Protein Aldehyde reductase (dehydrogenase), ALDH [53722] (9 species)

7. Species Human (Homo sapiens), mitochondrial [TaxId:9606] [53726] (27 PDB entries)
   Uniprot P05091

8. Domain d2onne_: 2onn E: [166783]
   automated match to d1bi9a_
   mutant

Details for d2onne_

PDB Entry: 2onn, 2.75 Å

PDB Description: arg475gln mutant of human mitochondrial aldehyde dehydrogenase, apo form

PDB Compounds: (E:) aldehyde dehydrogenase

SCOPe Domain Sequences for d2onne_:

Sequence; same for both SEQRES and ATOM records:

>d2onne_ c.82.1.1 (E:) Aldehyde reductase (dehydrogenase), ALDH {Human (Homo sapiens), mitochondrial [TaxId: 9606]}
avpapnqqpevfcnqifinnewhdavsrktfptvnpstgevicqvaegdkedvdkavkaa
raafqlgspwrrmdashrgrllnrladlierdrtylaaletldngkpyvisylvdldmvl
kclryyagwadkyhgktipidgdffsytrhepvgvcgqiipwnfpllmqawklgpalatg
nvvvmkvaeqtpltalyvanlikeagfppgvvnivpgfgptagaaiashedvdkvaftgs
teigrviqvaagssnlkrvtlelggkspniimsdadmdwaveqahfalffnqgqcccags
rtfvqediydefversvaraksrvvgnpfdskteqgpqvdetqfkkilgyintgkqegak
llcgggiaadrgyfiqptvfgdvqdgmtiakeeifgpvmqilkfktieevvgrannstyg
laaavftkdldkanylsqalqagtvwvncydvfgaqspfggykmsgsgqelgeyglqayt
evktvtvkvpqkns

Timeline for d2onne_:

• d2onne_ first appeared in SCOPe 2.01
  
• d2onne_ appears in SCOPe 2.07