SCOPe 2.04: Domain d2oaha_: 2oah A:

Lineage for d2oaha_ (2oah A:)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (242 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d2oaha_: 2oah A: [166603]
   automated match to d1fkna_
   complexed with qin

Details for d2oaha_

PDB Entry: 2oah, 1.8 Å

PDB Description: crystal structure of human beta secretase complexed with inhibitor

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d2oaha_:

Sequence, based on SEQRES records:

>d2oaha_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
rrgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqr
qlsstyrdlrkgvyvpytqgawagelgtdlvsiphgpnvtvraniaaitesdkffingsn
wegilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsm
iiggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnl
rlpkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnq
sfritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigf
avsachvhdefrtaavegpfvtldmedcgyn

Sequence, based on observed residues (ATOM records):

>d2oaha_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
rrgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqr
qlsstyrdlrkgvyvpytqgawagelgtdlvsiphgpnvtvraniaaitesdkffingsn
wegilglayaeiarpddslepffdslvkqthvpnlfslqlcgaggsmiiggidhslytgs
lwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavks
ikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylr
pvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrt
aavegpfvtldmedcgyn

Timeline for d2oaha_:

• d2oaha_ first appeared in SCOPe 2.01
  
• d2oaha_ appears in SCOPe 2.03
  
• d2oaha_ appears in SCOPe 2.05
  
• d2oaha_ appears in the current release, SCOPe 2.08