Lineage for d2itqa_ (2itq A:)

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2218047Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2218048Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2218179Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2220941Protein automated matches [190091] (17 species)
    not a true protein
  7. 2221040Species Human (Homo sapiens) [TaxId:9606] [188447] (653 PDB entries)
  8. 2221591Domain d2itqa_: 2itq A: [165686]
    automated match to d1m14a_
    complexed with itq; mutant

Details for d2itqa_

PDB Entry: 2itq (more details), 2.68 Å

PDB Description: Crystal structure of EGFR kinase domain G719S mutation in complex with AFN941
PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d2itqa_:

Sequence, based on SEQRES records: (download)

>d2itqa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlssgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsn
fyralmdeedmddvvdadeyli

Sequence, based on observed residues (ATOM records): (download)

>d2itqa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlssgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdmddvvdadeyli

SCOPe Domain Coordinates for d2itqa_:

Click to download the PDB-style file with coordinates for d2itqa_.
(The format of our PDB-style files is described here.)

Timeline for d2itqa_: