SCOPe 2.08: Domain d2itpa_: 2itp A:

Lineage for d2itpa_ (2itp A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d2itpa_: 2itp A: [165685]
   automated match to d1m14a_
   complexed with aee; mutant

Details for d2itpa_

PDB Entry: 2itp, 2.74 Å

PDB Description: crystal structure of egfr kinase domain g719s mutation in complex with aee788

PDB Compounds: (A:) epidermal growth factor receptor precursor

SCOPe Domain Sequences for d2itpa_:

Sequence, based on SEQRES records:

>d2itpa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlssgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsn
fyralmdeedmddvvdadeyli

Sequence, based on observed residues (ATOM records):

>d2itpa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlssgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdmdeedmddvvda
deyli

Timeline for d2itpa_:

• d2itpa_ first appeared in SCOPe 2.01
  
• d2itpa_ appears in SCOPe 2.07