Lineage for d2ilma_ (2ilm A:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2070014Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies)
    one turn of helix is made by two pairs of antiparallel strands linked with short turns
    has appearance of a sandwich of distinct architecture and jelly-roll topology
  4. 2070786Superfamily b.82.2: Clavaminate synthase-like [51197] (16 families) (S)
    Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold
  5. 2070961Family b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1) [82194] (1 protein)
  6. 2070962Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) [82195] (1 species)
  7. 2070963Species Human (Homo sapiens) [TaxId:9606] [82196] (34 PDB entries)
  8. 2070972Domain d2ilma_: 2ilm A: [165609]
    automated match to d1iz3a_
    complexed with akg, bct, fe2, gol, so4; mutant

Details for d2ilma_

PDB Entry: 2ilm (more details), 2.3 Å

PDB Description: Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer
PDB Compounds: (A:) hypoxia-inducible factor 1 alpha inhibitor

SCOPe Domain Sequences for d2ilma_:

Sequence, based on SEQRES records: (download)

>d2ilma_ b.82.2.6 (A:) Hypoxia-inducible factor HIF ihhibitor (FIH1) {Human (Homo sapiens) [TaxId: 9606]}
avasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelieneepvvltdt
nlvypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkprsnreemkfhe
fveklqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwgqltsnll
ligmegnvtpahyaeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqsqvdfdnp
dyerfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykgaptpkrie
yplkahqkvaimrniekmlgealgnpqevgpllntmikgryn

Sequence, based on observed residues (ATOM records): (download)

>d2ilma_ b.82.2.6 (A:) Hypoxia-inducible factor HIF ihhibitor (FIH1) {Human (Homo sapiens) [TaxId: 9606]}
avasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelieneepvvltdt
nlvypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkprsnreemkfhe
fveklqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwgqltsnll
ligmegnvtpahyaeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqsqvdfdnp
dyerfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykgaptpkiey
plkahqkvaimrniekmlgealgnpqevgpllntmikgryn

SCOPe Domain Coordinates for d2ilma_:

Click to download the PDB-style file with coordinates for d2ilma_.
(The format of our PDB-style files is described here.)

Timeline for d2ilma_: