SCOPe 2.03: Domain d2ikob_: 2iko B:

Lineage for d2ikob_ (2iko B:)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Chymosin (synonym: renin) [50667] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50669] (57 PDB entries)

8. Domain d2ikob_: 2iko B: [165603]
   automated match to d1bila_
   complexed with 7ig

Details for d2ikob_

PDB Entry: 2iko, 1.9 Å

PDB Description: Crystal Structure of Human Renin Complexed with Inhibitor

PDB Compounds: (B:) renin

SCOPe Domain Sequences for d2ikob_:

Sequence, based on SEQRES records:

>d2ikob_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
lgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhk
lfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmla
efdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsd
pqhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssiekl
mealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaiha
mdippptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records):

>d2ikob_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
lgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhk
lfdasdsssykhngteltlvsgflsqdiitvggitvtqmfgevtempalpfmlaefdgvv
gmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdpqhyeg
nfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealga
kkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippp
tgptwalgatfirkfytefdrrnnrigfalar

Timeline for d2ikob_:

• d2ikob_ first appeared in SCOPe 2.01
  
• d2ikob_ appears in SCOPe 2.02
  
• d2ikob_ appears in SCOPe 2.04
  
• d2ikob_ appears in the current release, SCOPe 2.08