SCOPe 2.06: Domain d2i0ja_: 2i0j A:

Lineage for d2i0ja_ (2i0j A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (64 PDB entries)
   Uniprot P03372 307-551

8. Domain d2i0ja_: 2i0j A: [165352]
   automated match to d1pcga_
   complexed with i0g

Details for d2i0ja_

PDB Entry: 2i0j, 2.9 Å

PDB Description: benzopyrans are selective estrogen receptor beta agonists (serbas) with novel activity in models of benign prostatic hyperplasia

PDB Compounds: (A:) Estrogen receptor alpha

SCOPe Domain Sequences for d2i0ja_:

Sequence, based on SEQRES records:

>d2i0ja_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysm

Sequence, based on observed residues (ATOM records):

>d2i0ja_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtli
hlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysm

Timeline for d2i0ja_:

• d2i0ja_ first appeared in SCOPe 2.01
  
• d2i0ja_ appears in SCOPe 2.05
  
• d2i0ja_ appears in SCOPe 2.07
  
• d2i0ja_ appears in the current release, SCOPe 2.08