SCOPe 2.08: Domain d2i0ea_: 2i0e A:

Lineage for d2i0ea_ (2i0e A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d2i0ea_: 2i0e A: [165350]
   automated match to d1xjda_
   complexed with pds

Details for d2i0ea_

PDB Entry: 2i0e, 2.6 Å

PDB Description: Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor

PDB Compounds: (A:) Protein Kinase C-beta II

SCOPe Domain Sequences for d2i0ea_:

Sequence, based on SEQRES records:

>d2i0ea_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ltdfnflmvlgkgsfgkvmlserkgtdelyavkilkkdvviqdddvectmvekrvlalpg
kppfltqlhscfqtmdrlyfvmeyvnggdlmyhiqqvgrfkephavfyaaeiaiglfflq
skgiiyrdlkldnvmldseghikiadfgmckeniwdgvttktfcgtpdyiapeiiayqpy
gksvdwwafgvllyemlagqapfegededelfqsimehnvaypksmskeavaickglmtk
hpgkrlgcgpegerdikehaffryidweklerkeiqppykpkacgrnaenfdrfftrhpp
vltppdqevirnidqsefegfsfvnseflkp

Sequence, based on observed residues (ATOM records):

>d2i0ea_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ltdfnflmvlgkgsfgkvmlserkgtdelyavkilkkdvviqdddvectmvekrvlalpg
kppfltqlhscfqtmdrlyfvmeyvnggdlmyhiqqvgrfkephavfyaaeiaiglfflq
skgiiyrdlkldnvmldseghikiadfgmckeniwdgvttktfcgtpdyiapeiiayqpy
gksvdwwafgvllyemlagqapfegededelfqsimehnvaypksmskeavaickglmtk
hpgkrlgcgpegerdikehaffryidweklerkeiqppykpkacgrenfdrfftrhppvl
tppdqevirnidqsefegfsfvnseflkp

Timeline for d2i0ea_:

• d2i0ea_ first appeared in SCOPe 2.01
  
• d2i0ea_ appears in SCOPe 2.07