SCOPe 2.08: Domain d2hzib_: 2hzi B:

Lineage for d2hzib_ (2hzi B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Abelsone tyrosine kinase (abl) [56166] (2 species)
   PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [226825] (5 PDB entries)

8. Domain d2hzib_: 2hzi B: [165343]
   automated match to d1opja_
   complexed with jin

Details for d2hzib_

PDB Entry: 2hzi, 1.7 Å

PDB Description: Abl kinase domain in complex with PD180970

PDB Compounds: (B:) Proto-oncogene tyrosine-protein kinase ABL1

SCOPe Domain Sequences for d2hzib_:

Sequence, based on SEQRES records:

>d2hzib_ d.144.1.7 (B:) Abelsone tyrosine kinase (abl) {Human (Homo sapiens) [TaxId: 9606]}
dkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmke
ikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissame
ylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapesla
ynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelm
racwqwnpsdrpsfaeihqafetmfqes

Sequence, based on observed residues (ATOM records):

>d2hzib_ d.144.1.7 (B:) Abelsone tyrosine kinase (abl) {Human (Homo sapiens) [TaxId: 9606]}
dkwemertditmkhklgggqygevyegvwkkysltvavktlmeveeflkeaavmkeikhp
nlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissameylek
knfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslaynkf
siksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmracw
qwnpsdrpsfaeihqafetmfqes

Timeline for d2hzib_:

• d2hzib_ first appeared in SCOPe 2.01
  
• d2hzib_ appears in SCOPe 2.07