SCOPe 2.05: Domain d1lpea_: 1lpe A:

Lineage for d1lpea_ (1lpe A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.24: Four-helical up-and-down bundle [47161] (28 superfamilies)
   core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

4. Superfamily a.24.1: Apolipoprotein [47162] (1 family)

5. Family a.24.1.1: Apolipoprotein [47163] (1 protein)
   Can exist in a coiled-coil oligomeric form, see PDB entry 1AV1
   family may also include the five-helical bundle protein Apolipophorin-III

6. Protein Apolipoprotein E [88703] (3 species)

7. Species Human (Homo sapiens), E3 [TaxId:9606] [47165] (7 PDB entries)

8. Domain d1lpea_: 1lpe A: [16524]

Details for d1lpea_

PDB Entry: 1lpe, 2.25 Å

PDB Description: three-dimensional structure of the ldl receptor-binding domain of human apolipoprotein e

PDB Compounds: (A:) apolipoprotein e3

SCOPe Domain Sequences for d1lpea_:

Sequence; same for both SEQRES and ATOM records:

>d1lpea_ a.24.1.1 (A:) Apolipoprotein E {Human (Homo sapiens), E3 [TaxId: 9606]}
gqrwelalgrfwdylrwvqtlseqvqeellssqvtqelralmdetmkelkaykseleeql
tpvaeetrarlskelqaaqarlgadmedvcgrlvqyrgevqamlgqsteelrvrlashlr
klrkrllrdaddlqkrlavyqaga

Timeline for d1lpea_:

• d1lpea_ first appeared (with stable ids) in SCOP 1.55, called d1lpe__
  
• d1lpea_ appears in SCOPe 2.04
  
• d1lpea_ appears in SCOPe 2.06
  
• d1lpea_ appears in the current release, SCOPe 2.08