SCOPe 2.06: Domain d2h4ha_: 2h4h A:

Lineage for d2h4ha_ (2h4h A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein NAD-dependent deacetylase NpdA [142126] (1 species)

7. Species Thermotoga maritima [TaxId:2336] [142127] (7 PDB entries)
   Uniprot Q9WYW0 1-245

8. Domain d2h4ha_: 2h4h A: [164944]
   automated match to d1yc5a1
   complexed with nad, zn; mutant

Details for d2h4ha_

PDB Entry: 2h4h, 1.99 Å

PDB Description: sir2 h116y mutant-p53 peptide-nad

PDB Compounds: (A:) NAD-dependent deacetylase

SCOPe Domain Sequences for d2h4ha_:

Sequence, based on SEQRES records:

>d2h4ha_ c.31.1.5 (A:) NAD-dependent deacetylase NpdA {Thermotoga maritima [TaxId: 2336]}
mkmkefldllnesrltvtltgagistpsgipdfrgpngiykkysqnvfdidffyshpeef
yrfakegifpmlqakpnlahvllakleekglieavitqnidrlhqragskkvielygnve
eyycvrcekkytvedvikklessdvplcddcnslirpnivffgenlpqdalreaiglssr
aslmivlgsslvvypaaelplitvrsggklvivnlgetpfddiatlkynmdvvefarrvm
eeggis

Sequence, based on observed residues (ATOM records):

>d2h4ha_ c.31.1.5 (A:) NAD-dependent deacetylase NpdA {Thermotoga maritima [TaxId: 2336]}
mkmkefldllnesrltvtltgagistpsgipdfrgpnvfdidffyshpeefyrfakegif
pmlqakpnlahvllakleekglieavitqnidrlhqragskkvielygnveeyycvrcek
kytvedvikklessdvplcddcnslirpnivffgenlpqdalreaiglssraslmivlgs
slvvypaaelplitvrsggklvivnlgetpfddiatlkynmdvvefarrvmeeggis

Timeline for d2h4ha_:

• d2h4ha_ first appeared in SCOPe 2.01
  
• d2h4ha_ appears in SCOPe 2.05
  
• d2h4ha_ appears in SCOPe 2.07
  
• d2h4ha_ appears in the current release, SCOPe 2.08