SCOPe 2.08: Domain d2gs7a_: 2gs7 A:

Lineage for d2gs7a_ (2gs7 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (133 PDB entries)
   Uniprot P00533 702-1018

8. Domain d2gs7a_: 2gs7 A: [164827]
   automated match to d1m14a_
   complexed with anp, iod, mg

Details for d2gs7a_

PDB Entry: 2gs7, 2.6 Å

PDB Description: crystal structure of the inactive egfr kinase domain in complex with amp-pnp

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d2gs7a_:

Sequence, based on SEQRES records:

>d2gs7a_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
llrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeilde
ayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqia
kgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikwma
lesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictid
vymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralm
deedmddvvd

Sequence, based on observed residues (ATOM records):

>d2gs7a_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
llrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeilde
ayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqia
kgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhkvpikwmalesi
lhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymi
mrkcwmidadsrpkfreliiefskmardpqrylviqgdvvd

Timeline for d2gs7a_:

• d2gs7a_ first appeared in SCOPe 2.01
  
• d2gs7a_ appears in SCOPe 2.07