SCOPe 2.05: Domain d2g5oa_: 2g5o A:

Lineage for d2g5oa_ (2g5o A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (61 PDB entries)
   Uniprot P03372 307-551

8. Domain d2g5oa_: 2g5o A: [164583]
   automated match to d1qkua_
   complexed with drq

Details for d2g5oa_

PDB Entry: 2g5o, 2.3 Å

PDB Description: human estrogen receptor alpha ligand-binding domain in complex with 2- (but-1-enyl)-17beta-estradiol and a glucocorticoid receptor interacting protein 1 nr box ii peptide

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d2g5oa_:

Sequence, based on SEQRES records:

>d2g5oa_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
nslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakr
vpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmve
ifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkit
dtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllem
ldahr

Sequence, based on observed residues (ATOM records):

>d2g5oa_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
nslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakr
vpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmve
ifdmllatssrfrmmnlqgeefvclksiillnsgvytfleekdhihrvldkitdtlihlm
akagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahr

Timeline for d2g5oa_:

• d2g5oa_ first appeared in SCOPe 2.01
  
• d2g5oa_ appears in SCOPe 2.04
  
• d2g5oa_ appears in SCOPe 2.06
  
• d2g5oa_ appears in the current release, SCOPe 2.08