SCOPe 2.08: Domain d2g27b_: 2g27 B:

Lineage for d2g27b_ (2g27 B:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Chymosin (synonym: renin) [50667] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50669] (77 PDB entries)

8. Domain d2g27b_: 2g27 B: [164560]
   automated match to d1bbsa_
   complexed with 4lg

Details for d2g27b_

PDB Entry: 2g27, 2.9 Å

PDB Description: Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring

PDB Compounds: (B:) renin

SCOPe Domain Sequences for d2g27b_:

Sequence, based on SEQRES records:

>d2g27b_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklfdas
dsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaefdgv
vgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdpqhye
gnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealg
akkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdipp
ptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records):

>d2g27b_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklfdas
dsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaefdgv
vgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdslggqivlggsdpqhyegnfhy
inliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealgakkrl
fdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippptgpt
walgatfirkfytefdrrnnrigfalar

Timeline for d2g27b_:

• d2g27b_ first appeared in SCOPe 2.01
  
• d2g27b_ appears in SCOPe 2.07