Lineage for d2g21a_ (2g21 A:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2058814Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2058815Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2060177Family b.50.1.2: Pepsin-like [50646] (11 protein domains)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 2060651Protein Chymosin (synonym: renin) [50667] (3 species)
  7. 2060659Species Human (Homo sapiens) [TaxId:9606] [50669] (76 PDB entries)
  8. 2060696Domain d2g21a_: 2g21 A: [164551]
    automated match to d1bbsa_
    complexed with l1b

Details for d2g21a_

PDB Entry: 2g21 (more details), 2.2 Å

PDB Description: Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring
PDB Compounds: (A:) renin

SCOPe Domain Sequences for d2g21a_:

Sequence, based on SEQRES records: (download)

>d2g21a_ b.50.1.2 (A:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklfdas
dsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaefdgv
vgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdpqhye
gnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealg
akkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdipp
ptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records): (download)

>d2g21a_ b.50.1.2 (A:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklfdas
dsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaefdgv
vgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdselggqivlggsdpqhyegnfh
yinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealgakkr
lfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippptgp
twalgatfirkfytefdrrnnrigfalar

SCOPe Domain Coordinates for d2g21a_:

Click to download the PDB-style file with coordinates for d2g21a_.
(The format of our PDB-style files is described here.)

Timeline for d2g21a_: