Lineage for d2f29a_ (2f29 A:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2064980Fold b.68: 6-bladed beta-propeller [50938] (11 superfamilies)
    consists of six 4-stranded beta-sheet motifs; meander
  4. 2064981Superfamily b.68.1: Sialidases [50939] (3 families) (S)
  5. 2064982Family b.68.1.1: Sialidases (neuraminidases) [50940] (10 protein domains)
  6. 2065211Protein Sialidase 2 (Neu2) [117274] (1 species)
  7. 2065212Species Human (Homo sapiens) [TaxId:9606] [117275] (14 PDB entries)
    Uniprot Q9Y3R4
  8. 2065228Domain d2f29a_: 2f29 A: [164260]
    automated match to d1vcua_
    complexed with dan, epe; mutant

Details for d2f29a_

PDB Entry: 2f29 (more details), 2.92 Å

PDB Description: Crystal Structure of the Human Sialidase Neu2 Q116E Mutant in Complex with DANA Inhibitor
PDB Compounds: (A:) Sialidase 2

SCOPe Domain Sequences for d2f29a_:

Sequence, based on SEQRES records: (download)

>d2f29a_ b.68.1.1 (A:) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
maslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgdyd
apthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvteqqqletran
vtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpaya
yrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnarshl
rarvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythpth
swqradlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandye
eivflmftlkqafpaey

Sequence, based on observed residues (ATOM records): (download)

>d2f29a_ b.68.1.1 (A:) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
maslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgdyd
apthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvteqqqletran
vtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpaya
yrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaeveqrvvtlnarshlrar
vqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprspaqwllythpthswqradl
gaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandyeeivflmf
tlkqafpaey

SCOPe Domain Coordinates for d2f29a_:

Click to download the PDB-style file with coordinates for d2f29a_.
(The format of our PDB-style files is described here.)

Timeline for d2f29a_: